If you are only growing a few plants at a time, you want to be sure that they are all female from the very beginning by purchasing feminized seeds. Of course, the roots will have trouble spreading out if there is not enough space. A seed basically is a storage organ of high energy compounds, thus they are a favorite food source of insects and other organisms. Source: https://chokobank.biz/2024/02/07/from-seed-to-splendor-a-comprehensive-cannabis-cultivation-guide